Myostatin, a transforming growth factor-beta superfamily member, is very important in controlling muscle growth in vertebrates. It acts as a negative modulator of muscle mass by inhibiting myoblast proliferation and differentiation. It has been shown that natural mutations of the myostatin gene may give phenotypic variations in animals, including cattle and fish, which can include increased muscle mass and improved musculature, which have been described in both wild populations and selectively bred strains. These genetic variants show Myostatin`s evolutionary conservation and adaptive significance in fish physiology. So, the role of Myostatin in aquaculture provides opportunities for genetic improvement programs focused on enhancing growth traits in commercially important species. Selection strategies for positive myostatin mutations have been followed to increase the meat yield and raise production efficiency. Further opportunities to manipulate myostatin expression and activity in fish can be provided by gene editing technologies such as CRISPR-Cas9 and other biotechnological approaches. These innovations promise to produce genetically improved fish strains with superior growth characteristics and resilience against environmental stressors. The study of Myostatin in fish not only enhances our understanding of muscle biology and development and offers practical applications for improving aquaculture productivity and sustainability. The articles describe how Myostatin controls muscle growth in fish and its importance.