Fish smoking is widely practiced in Manipur since time immemorial for its culinary, therapeutics and ritual purposes. A unique smoking process without salt or other preservatives is followed. Smoking is performed by women folks located in and around the Loktak lake, the biggest freshwater lake in North-East India. The smoking practices is still artisanal and remain unfamiliar to the rest of India though smoked fish production plays a vital role in state economy, food and protein security. Smoked fish play a significant role in Manipuri cuisine and often eat daily. During ailment when oily foods are restricted smoked fishes are generally consumed. Smoked fish are also indispensable for important rituals. For instance, smoked fishes are offered to God during the first ceremony of child birth called Epanthaba. Therefore, the present article discusses about the method of preparation, its uses, and possible safety concern of smoked fish of Manipur.