High temperatures negatively impact plant growth, physiology, and yield by generating harmful reactive oxygen species (ROS) that damage cells. Plants employ enzymatic and non-enzymatic antioxidant systems to counteract these effects. Trehalose, a non-reducing disaccharide, has emerged as a crucial stress protector in plants. This article examines trehalose`s role in mitigating combined drought and heat stress in wheat. Trehalose acts as a compatible solute, preserving cellular structure during dehydration, and stabilizes biological structures even at high temperatures. External trehalose application boosts antioxidant enzyme activity, reduces ROS accumulation, and enhances photosynthesis and growth in wheat. Genetic modification to increase trehalose synthesis offers promise for developing heat-tolerant crops. Trehalose also activates stress-related genes, presenting a strategy for enhancing crop resilience. Its exogenous use effectively mitigates drought`s impact, promoting growth, yield, and antioxidant defense in various plants. Trehalose is a compelling tool for fortifying crops against dual drought and heat stress, with multifaceted protective and regulatory functions for sustainable agriculture amidst changing climates.